Candesartan, Candesartan cilexetil, angiotensin II receptor antagonists, hydrochlorothiazide, diuretic, antihypertensive, antihypertensive


Atacand PLUS® is a drug used to treat high blood pressure (hypertension) in adults. It is a combination preparation of the two active ingredients candesartan and hydrochlorothiazide. Candesartan dilates the blood vessels, while hydrochlorothiazide has a dehydrating effect. Both lead to a decrease in blood pressure.

Atacand PLUS is usually administered when the blood pressure cannot be brought under control by therapy with monopreparations (e.g. candesartan only).

How Atacand PLUS® works

The two active ingredients Candesartan cilexetil and hydrochlorothiazide show a complementary effect on each other Lowering blood pressure. Candesartan cilexetil is a Prodrugwhich only occurs when passing the Gastrointestinal tract is converted into the active form and can then develop its full effect as candesartan.

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Candesartan is a Angiotensin I receptor antagonist. Angiotensin II plays an important role in the RAAS, the renin-angiotensin-aldosterone system. This system is in the human body for that Regulation of blood pressure and water balance responsible. Angiotensin II results in a Narrowing of blood vessels and an increased distribution of Aldosterone in the adrenal cortex. Aldosterone now increasingly holds back sodium and water in the body, these are no longer over kidney eliminated. Both processes make for one Increase in blood pressure in the body.

The angiotensin II effect is mediated via angiotensin I receptors. If these are now inhibited by candesartan, it comes to Widening of the blood vessels, moreover, water and sodium more excreted - blood pressure drops. The hydrochlorothiazide has a dehydrating effect. It inhibits the sodium-chloride cotransporter in the kidney tubules, thereby increasing the amount of sodium, chloride, water and also small parts potassium eliminated. In the blood vessels becomes thereby the volume decreased, it comes to Drop in blood pressure.

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Atacand PLUS is prescription only and available as tablet in the following doses: 8 / 12.5 mg, 16 / 12.5 mg, 32 / 12.5 mg, there is also Atacand PLUS forte in the dosage 32/25 mg. The first indication stands for the Candesartan cilexetil- Share and the second statement refers to the Hydrochlorothiazide part of the drug.


Atacand PLUS is taken always in consultation with the attending physician, usually one tablet per day is prescribed. This should go together with a few sips of water be taken, preferably at the same time of day.

Side effects of Atacand PLUS®

Often it happens to decreased sodium levels and increased or decreased levels of potassium in the blood, as a result of which one feels weakness, Lack of energy, muscle cramps occur and it can irregular heartbeat come.

Furthermore, higher amounts can be used cholesterol, sugar or uric acid occur in the blood. Dizziness, headaches and also respiratory infections are not uncommon.

Occasional side effects are Loss of appetite, diarrhea, constipation, nausea and vomiting, rash and drop in blood pressure. The intake of Atacand PLUS® can rarely die Kidney function affect, too sleep disorders to lead, high fever cause a Inflammation of the pancreas cause or the number of reden and white blood cells and the Platelets decrease, resulting in a general immune system weakness and susceptibility to infection. Are very rare allergic reaction or one Inflammation of the liver.

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Contraindication of Atacand PLUS®

Atacand PLUS® is allowed not prescribed if the patient is known to have:

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  • allergy against one of the active ingredients
  • heavy Kidney / biliary / liver dysfunction
  • chronic potassium deficiency
  • Calcium excess

in blood. Also Children and pregnant women must not be treated with the combined preparation. Particular care should be taken during treatment Kidney and liver dysfunction, Valve defects, coronary artery disease, diabetes, syst. Lupus erythematosus, Conn syndrome and previous ones stroke.

Similar drugs

Eprosartan + hydrochlorothiazide (e.g. Emestar plus®, Teveten plus®), irbesartan + hydrochlorothiazide (e.g. CoAprovel®), Losartan + hydrochlorothiazide (e.g. Lorzaar plus®), Telmisartan + hydrochlorothiazide (e.g. Micardis plus®)

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