Palladon® (Hydromorphone) is one of the very strong semi-synthetic opioid analgesics.
It is 10 times and more potent than morphine.
It is used to treat very severe acute and chronic pain and requires a prescription.
Trade name: Palladon®, Dilaudid®
Chemical name: hydromorphone, hydroxy-17-methyl-4,5-epoxymorphinan-6-one (IUPAC formula)
Molecular chemical formula: C17H19NO3 (Hydromorphone), C17H19NO3 · HCl (Hydromorphone hydrochloride)
The use of Palladon® is indicated in very severe pain such as tumor diseases, neuropathies, postoperative pain or severe trauma.
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In addition, it can also be used as a Antitussive be used.
An antitussive is a medicine that prevents the to cough dampens.
In Germany, however, they prefer to use this Codeine and Dihydrocodeine.
Palladon® can on the one hand be taken orally in the form of a capsule or retard capsule, on the other hand it can be administered as an injection solution.
A Retard capsule is a special dosage form in which the active ingredient is released slowly in doses. In this way, the patient is constantly supplied with the active ingredient over a certain period of time.
The dosage of Palladon® is different and varies depending on the severity of the pain to be treated.
Usually the starting dose is 4mg every 12 hours.
The drug is not suitable for children under 12 years.
Since it is only available on prescription, an appropriate dosage for the respective patient is always discussed and determined with the attending physician.
$config[ads_text2] not foundPalladon® is with the Morphines related.
It is a hydrogenated morphine ketone and a metabolite of Morphine, Codeine and Dihydrocodeine.
A metabolite is a product of metabolism. It has a low plasma protein binding.
This offers an important advantage in the treatment of very thin patients, as these are already low in content protein in their blood plasma due to their nutritional status.
As already mentioned, Palladon® belongs to the opioid analgesics.
These drugs act on our body's own pain-relieving system.
It mimics the effects of the body's own opioid peptides (Egg whites) such as the Endorphins and Enkephalins to.
The Prevents pain transmission. This means that the pain stimulus does not even occur in higher processing centers of ours Brainlike that Thalamus or that limbic system arrives and we are not aware of it.
Palladon® forms few active metabolites (Metabolic products) and is therefore also very suitable for patients with Kidney failure.
As already mentioned, the plasma protein formation is very low, so Palladon® does not interact so much with other drugs, which is another advantage.
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The side effects of Palladon® are typical for the active substance class of Opioid analgesics.
It can too nausea, Vomit and dizziness come.
Also can Constipation and Urinary retention occur.
As with many pain reliever medicines, you can fatigue and low blood pressure (Hypotension), as well as a Bradycardia and Respiratory depression be the consequence.
Constricted pupils (Miosis) can be a sign of overdose.
$config[ads_text2] not foundIn addition, hydromorphone has one euphoric effect and therefore a certain Addictive potentialthat a dependency can result.
Furthermore can Hallucinations and a Hyperhidrosis (excessive sweating) occur when taking Palladon®.
The effect of hydromorphone can be increased and influenced by the simultaneous use of sedative drugs. There may be more side effects.
These medicines include Muscle relaxants, Barbiturates, Benzodiazepines, Phenotiazines (Neuroleptics e.g. for use in hallucinations), Tricyclic antidepressants and Anesthetics.
There are also interactions with alcohol, Antihistamines (for the treatment of allergies and inflammation of the mucous membranes) and Tranquilizers (anxiety-relieving psychopharmacama) known.
The use of Palladon® is contraindicated in a allergy against hydromorphone, breathing difficulties such as respiratory depression, asthma and one chronic obstructive pulmonary disease (COPD) and one paralytic ileus.
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