Citromax ® (also Zithromax) is the trade name of a drug. The active substance contained therein is the antibiotic azithromycin. This works against various bacterial infections.
Citromax ® is a prescription and can only be prescribed by a doctor. Commercially available are Citromax ® film-coated tablets with different dosages (250mg, 500mg and 600mg azithromycin). In addition, the active ingredient azithromycin is still offered as eye drops and as an infusion solution.

active substance

The active ingredient in Citromax ®, azithromycin, is antibacterial.

In addition to azithromycin, the active substances erythromycin, clarithromycin, roxithromycin and many more belong to the group of macrolide antibiotics. These inhibit the proliferation of bacteria by inhibiting protein synthesis in the bacteria. Human protein synthesis is not attacked because it is made in human cells by other enzymes than in bacterial cells. Since macrolides, such as Citromax ® only inhibit bacterial growth, but cause no killing of the bacteria, it is called a bacteriostatic effect. In this case, macrolides only act against dividing bacteria, while they are ineffective in dormant bacteria.

In addition to this direct bacteriostatic effect, there is evidence of an influence on the immune system by macrolides. This effect occurs even at low doses and has a positive effect especially in chronic inflammation.

application areas

Citromax ® is effective against a variety of bacteria and is therefore one of the broad-spectrum antibiotics. This means that it is usually applied inital as long as the exact pathogen has not yet been found (calculated antibiotic therapy). If this is known, a switch to a specifically directed against this pathogen effective antibiotic drug should be made. Thus, resistance of bacteria to certain antibiotics can be prevented (specific antibiotic therapy).

In particular, macrolides are used in penicillin allergy and infections with staphylococci, streptococci and pneumococci. In addition, macrolides additionally act against pathogens that attack the respiratory tract (hemophilus influenza) and also against bacteria that multiply within the cells (legionella, chlamydia, mycoplasma).

In particular, Citromax ®, or the antibiotic azithromycin in the form of tablets or as a solution for infusion in the inpatient area, is considered the drug of choice in pneumonia in the home environment.

Also in certain sexually transmitted diseases (gonorrhea, infection with Chlamydia trachomatis) Azithromycin is prescribed. Also against certain atypical mycobacteria (eg Mycobacterium avium) works Citromax ® .

Common diseases that can be treated with Citromax® are

  • Respiratory tract infections: sinusitis, pharyngitis, otitis, tonsillitis, pneumonia
  • Infections of skin and soft tissue
  • Infections by chlamydia in the genital area (inflammation of the urethra or cervix)
  • Inflammation in the eye area: purulent conjunctivitis

Taking Citromax®

The tablets should be swallowed whole. This can be done together with the meal. Only the simultaneous use of drugs to reduce gastric acid production (antacids) should be avoided. Here is a break of 60-120 minutes between taking the medication.

The duration of the intake is on average three to five days, with the once-daily intake is sufficient. In children, the intake dose is based on body weight.

side effects

Overall, the macrolide antibiotics, as well as Citromax ®, are well tolerated.

  • Common side effects: allergic skin reactions, nausea, vomiting, diarrhea, headache

  • Citromax® QT prolongation: Citromax® may cause a delay in electrical cardiac conduction. This can lead to a prolonged QT interval, which in turn can cause other life-threatening cardiac arrhythmias. Therefore, before taking an ECG should be written from the heart and the concomitant use of other drug with this side effect should be avoided.

  • Incompatibility with the concomitant use of the following medications: including statins, terfenadine, theophylline, carbamazepine. This may lead to fluctuations in drug levels due to drug-drug interactions.

pregnancy and breast feeding period

Use of Citromax ® in pregnancy:

It has not been conclusively clarified whether Citromax ® causes damage to the unborn child. However, there is currently no contraindication to the use of this medicine in pregnancy.

Use of Citromax ® while breast-feeding:

Even during lactation, women can take Citromax ® . Sometimes it comes to diarrhea in the infant. It is recommended that the milk be pumped for the duration of taking the antibiotics and restenured from the third day after stopping the medication.

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