OTRIVEN

definition

Otriven ® contains the active substance xylometazoline hydrochloride .
It is a medicine of the group of rhinologics.
These are medicines that can be prescribed for use in the nose when you have a cold.

Dosage Form

nose drops

application

In a low dosage Otriven is also suitable for children.

The nose should be thoroughly cleaned before using Otriven ® Nasal Drops. Blowing is enough. The drops can then be instilled into each nostril with the head bowed back. Nasal drops should only be used by one person for hygienic reasons and to prevent infections.

Otriven ® should not be used for more than a week. A prolonged use should be discussed with a doctor. If this is not the case, a break of several days should be taken after seven days before restarting with Otriven ® Nasal Drops.

Otriven ® is less suitable for the treatment of chronic colds, as it can lead to a loss of the nasal mucosa if used too long. The recommended daily dose is one to two drops in each nostril up to three times.

mechanism of action

As mentioned above, Otriven® contains the active substance xylometazoline . It is a sympathomimetic, an agent that activates the sympathetic nervous system.

Because it only binds to the alpha receptor, it has a vasoconstrictor component in the nasal mucosa. The mucous membrane is less perfused and swells off. Within 5 to 10 minutes after using the nose drops, the effect occurs. Improved nasal breathing through mucosal swelling and better secretion drainage are the result of Otriven® nasal drops. Xylometazoline is usually used in salt form. This is possible by means of hydrochloride.

Otriven® nose drops are over-the-counter and can be purchased at the pharmacy.

application areas

Otriven® is used in the following conditions: rhinitis vasomotorica: a seizure syndrome occurring in fits; Allergic rhinitis: allergic rhinitis; Sinusitis and otitis media associated with runny nose: by facilitating the drainage of the nasal secretion, the Eustachian tube or the sinuses can be better ventilated again and a healing occurs more quickly.

Contraindications

If one of the following applies, Otriven® must not be used with:

  • an already existing hypersensitivity reaction to xylometazoline or other components of Otriven®
  • an existing hypersensitivity reaction to the preservative benzalkonium chloride
  • Children under two years only after consultation with a pediatrician and
  • after surgical removal of the pineal gland (pituitary gland) and any other surgical procedures that expose the meninges.

Limited applications

Otriven® may only be used in consultation with the attending physician for the following conditions:

  • severe cardiovascular diseases such as coronary heart disease, hypertension or angina pectoris
  • concomitant use of MAO inhibitors
  • Simultaneous use of drugs that increase blood pressure
  • increased intraocular pressure as in narrow-angle glaucoma
  • Adrenal tumor (pheochromocytoma)
  • enlarged prostate
  • certain metabolic diseases such as porphyria
  • Hyperthyroidism
  • Blood sugar disease (diabetes mellitus).

Use in children

Otriven® 0.05% must not be prescribed in infants and toddlers under the age of two years. For this age group, an Otriven® containing 0.025% xylometazoline hydrochloride was specifically made. Children from two to six years of age may use Otriven® 0.05%.

Long-term use and too high a daily dose should be avoided. Long-term use and higher doses should only be under medical supervision.

For schoolchildren and adults, Otriven® nasal drops containing 0.1% xylometazoline hydrochloride are on the market. Again, the recommended daily allowance should not be exceeded to avoid any unwanted drug reactions.

Otriven® nose drops have no effect on the ability to drive.

Use in pregnancy and lactation

  • Pregnancy: There is insufficient evidence that Otriven® is a safe medicine during pregnancy, which is why Otriven® should only be prescribed after a risk-benefit assessment with the attending physician. The recommended dose should not be exceeded in order to avoid any subsequent damage to the unborn child. An overdose can lead to a nutrient deprivation of the unborn child.
  • Breast-feeding: As there is insufficient evidence for the safe use of Otriven® during breast-feeding, it should only be taken in consultation with the attending physician. The recommended daily dose should not be exceeded as Otriven® may reduce milk production.

side effects

Like other medicines, Otriven® can cause adverse drug reactions.

The most common side effect is an increasing swelling of the nasal mucosa after the active ingredient has decayed. Occasionally occurring side effects include: sneezing, nose bleeding, increased blood pressure, palpitations, rapid heartbeat, rash or itching. Less common are headaches, insomnia or tiredness after Otriven®. Also noteworthy are the unwanted drug reactions, which occur only very rarely: Hallucinations or convulsions can occur in children in the rarest of cases. Burning or dryness of the nasal mucosa can occur with too long, frequent use as well as with too high a dosage. The nasal mucous membrane can also increase swelling. The appearance occurs in the so-called rhinitis medicamentosa. Increased drug use triggers these symptoms. If the medication is not discontinued after the onset of these symptoms, lasting damage (barking) in the nasal mucosa may occur after continued use. The disease is also referred to as rhinitis sicca.

Measures for side effects

If side effects occur, they should be reported to the doctor. This decides on the countermeasures that should be taken.

If you experience sudden or severe side effects such as excessive blood pressure, severe headache or a hypersensitivity reaction, you should inform a doctor immediately.

A quick action is important to avoid any serious consequences.

interactions

The attending physician should be aware of any medication taking place recently or recently. Caution should be exercised with the concomitant use of Otriven® and mood-enhancing medicines, such as MAOIs or tricyclic antidepressants, as well as antihypertensive drugs. It can come to a momentous increase in blood pressure.

Overdose

The clinical picture of xylometazoline hydrochloride intoxication is varied.

Phases of activation may overlap with phases of central nervous system inhibition. Especially in children, it can lead to convulsions, coma, slow pulse or respiratory arrest after too high a dose. A rapidly occurring high blood pressure is quickly replaced by the blood pressure drop again. Other signs of overdose include hallucinations, anxiety, inner agitation, narrowing of the pupil (myosis), dilation of the pupil (mydirasis), fever, sweating, pallor, nausea or vomiting, cardiac arrhythmias.

If poisoned with Otriven®, seek medical advice immediately. The fastest possible treatment and monitoring in the hospital are necessary.

storage

Otriven ® should be stored at room temperature in its original packaging, protected from moisture and light. Generally, it should be kept out of the reach of children.

The drug may not be used after the expiration date. It should not be disposed of in household waste or wastewater.


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