Trade name: Capval®
Non-proprietary name: noscapine
Other chemical names: narcotine, methoxyhydrastine
(Molecular formula of noscapine: C22H23NO7
Capval® belongs to the group of antitussives, also known as cough suppressants.
Antitussives can act on the one hand by inhibiting the cough center in the brain stem (= central effect), on the other hand by inhibiting sensitive receptors in the lungs (= peripheral effect). It is important that this type of medication is only prescribed when the cough is dry (= without phlegm). Since the cough reflex is inhibited when the cough center in the brain stem is inhibited, existing mucus cannot be coughed up as a result, which might worsen the clinical picture.
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The active ingredient of Capval® is Noscapine. Noscapine is a natural component of opium, which as an alkaloid from the plant Opium poppy (Papaver somniferum) is obtained. It owns as Antitussive exclusively peripheral Effect. That means it acts directly on them Bronchi, where it bronchodilator (= dilating) and breath-stimulating Has an effect.
Capval® causes no pain relief (Analgesia) and is therefore not an opiate. In contrast to opiates (like for example Codeine) it is essential better tolerated and owns no addictive potential, because it does not trigger any euphoric effects.
The fact that it only works in the periphery results in another advantage: Capval® works neither sedating nor suppressed breathing. Also Constipation (= constipation), a common and very stressful side effect for those affected Opiate use, occurs when taking Capval® not on. In addition, according to recent studies, it should be a antitumor Have an effect because it inhibits CYP2C9.
$config[ads_text2] not foundThe Plasma half-life by Capval® lies between 2.6 and 4.5 hours. The molar mass is 413. The oral bioavailability, i.e. the percentage of the active ingredient that is available unchanged at the site of action (in this case the bronchi) is around 30%.
Antitussives, like Capval, are mainly used for the symptomatic treatment of unproductive (= without slime) nocturnal irritable cough applied. There to cough is never a disease in its own right, but only represents a symptom, must be the cause of the Irritable cough to be examined by a doctor.
A possible cause can be, for example acute or Chronic bronchitis be. Pertussis (whooping cough) can also be a prescription reason as well as COPD (Chronic obstructive pulmonary disease). Also by one tumor or some other anatomical change can occur cough form. If the to cough too strong Cardiovascula-Capval is equally induced. This is the case, for example, when a Aneurysm by the strong to cough could burst.
Common side effects are a headache and Drowsiness. Occasionally kick nausea and Vomit after ingestion. dizziness, Skin and hypersensitivity reactions with itching are also among the side effects. The training of a Quinke-Edema (Swelling of the face and neck) occurs occasionally. Also convulsive Upper abdominal pain With Anxiety and Shortness of breath have already been described, albeit rarely. Overdosing can lead to Seizures come.
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$config[ads_text3] not foundCapval® should not together with an expectorant be administered because the mucus that has formed so cannot be coughed up and it becomes a Secretion jam can come. In addition, the combination with drugs that have a central depressant effect (such as Sedatives, sleeping pills, Antidepressants, Neuroleptics, Opioids or alcohol) not recommended.
there has been a Interaction with the vitamin K-Antagonist warfarin (Coumadin), presumably based on the fact that Capval® inhibits the enzyme CYP2C9. Warfarin is a substrate of CYP2C9, which means that warfarin is metabolized via CYP2C9. When Capval® Now that CYP2C9 is inhibited, warfarin can accumulate in the body and thus become a Warfarin overdose comes because it can no longer be metabolized. This inhibition of CYP2C9 could therefore also be relevant for other drugs that are metabolized via CYP2C9: These include drugs Phenprocoumon, Phenytoin and Losartan.
Capval® may in case of known hypersensitivity reaction to the active substance noscapine not taken become. Capval also contains®Juice contains the components methyl or propyl 4-hydroxybenzoate, so that it should also not be taken if there is an allergy to one of these components. Capval® Juice and dragees also contain different types of sugar (contain dragees Lactose and Sucrose; Juice contains the sugar Sorbitol). If there is an intolerance to one of these types of sugar, the agent should only be taken after consulting a doctor.
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At heavy slime formation is Capval® counterproductivesince it is the Prevents coughing up the mucus. children under six months should be Capval® do not take, in children under two years of age should use Capval® can only be used on medical prescription.
Some sources say that Capval® during a pregnancy is contraindicated only in the first trimester. Others advise Waiver during the entire pregnancy.
If you want to be on the safe side, it's from Capval® not advisable during pregnancy as there are insufficient data on this.
When taking Capval® The infant is unlikely to be endangered during breastfeeding, as noscapine is only excreted in breast milk in small amounts. Still, Capval should® in the Lactation 2-3 days at most be taken.
After taking Capval® is urgent of it advised against Driving a car or other vehicles. You should too no electric tools or heavy machinery operate as Capval® the attention as well as that Impair the ability to react can. It is no longer possible to react quickly enough to sudden events. This can be especially true for Start of treatment and at Dose increase be the case.
Capval® comes in the form of Lozenges, drops, Capsules, Suppositories and as syrup.
Capval® Dragees usually included 25 mg noscapine per one coated tablet.
Capval® juice contains 25 mg noscapine in 5 g (which corresponds to about 5 ml).
In adults is Capval® in a dosage of 50-100 mg cough suppressant.
Capval® is prescription only, therefore only available by prescription.
Sedotussin is also a remedy for cough. Who on purely herbal remedies would like to fall back on, can deal with preparations from Prospan help.
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