Medulla ossium
The bone marrow fills the inside of the bone and is the main place of blood formation in humans.
Many diseases result from an imbalance in cell formation in the bone marrow. For example, leukemia and anemia (anemia), which can occur as part of many underlying diseases.
a - epiphysis
(Bone end)
b - metaphysis
(active growth zone)
c - diaphysis
(Bone shaft)
You can find an overview of all Dr-Gumpert images at: medical illustrations
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The Bone marrow lies at the core of the human bone and does about 2500 grams of body weight. It is divided into yellow and red Bone marrow.
The red bone marrow is the place of blood formation, the yellow, however, not, it is called fat marrow. In the newborn, the red bone marrow makes up the main part, but in the course of development it largely changes to yellow, so that in an adult red - blood-forming - bone marrow is only found in certain bones.
These include the bones of the trunk, as among other things Rib bones, Sternum, Vertebral bones, Pelvic bones and Collarbones, such as Skull bones and the end up (Epiphyses) the long tubular bones of the arm and leg.
Before the birth, play next to the Bone marrow Yet other organs play an important role in blood formation. The main places of blood formation between the 2nd and 7th month of the fetus are above all those liver and the spleen.
$config[ads_text2] not foundIn addition to blood formation, the bone marrow has another important function. It's part of the Immune system. A population of white blood cells - the B lymphocytes - that are essential for the immune system.
Blood formation begins in the bone marrow from so-called multipotent stem cells. This means that these cells can develop into any cell.
In the case of the Blood formation there are two possibilities as there are two large cell populations here.
An important disease of the bone marrow is the leukemia.
There are different forms of leukemia depending on whether it develops quickly or slowly and which cell lines are affected. However, they often have one thing in common:
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So a patient with leukemia can stand out paleness (anemia), increased bruises and bleeding from the skin that occur even with minor trauma (lack of platelets) and frequent infections (lack of functional lymphocytes).
$config[ads_text2] not foundAnother disease of the bone marrow is the Osteomyelitis, an inflammation that usually occurs through bacteria is conditional.
A so-called Bone marrow puncture, i.e. taking a sample from the bone marrow, can be an important step in the diagnosis of various diseases.
Among other things, if some types of leukemia are suspected and in some cases Hodgkin's disease and Non-Hodkin lymphoma and other diseases of the hematopoietic system (multiple myeloma, myelodysplastic syndrome).
Even when looking for Metastases (that is, the colonization of tumor cells) among others at Breast cancer (Breast cancer) and Lung cancer (Bronchial carcinoma) a bone marrow aspiration may be necessary.
Even if one of the rows of cells in the blood is increased or decreased (as is often the case with leukemia), this can be an indication for a bone marrow puncture.
The puncture is usually carried out on the iliac crest after prior anesthesia. A distinction is made between the type of bone marrow removal aspiration and a biopsy.
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It can be therapeutically very valuable to transplant certain blood cells, i.e. to supply them to a person.
These blood cells are stem cells that have the ability to develop into a wide variety of blood cells. One can do that transplantation with cells from the peripheral blood, similar to a blood donation (peripheral stem cell transplant) or using cells from the bone marrow.
The former sits opposite the Bone marrow donation always on through. A distinction is also made as to whether a patient's own cells are removed and re-administered (autologous stem cell transplant) or whether cells are taken from a compatible donor and then given to the recipient (allogeneic stem cell transplant).
In such a procedure, the ability to fit is essential (compatibility) of donors and recipients in relation to certain tissue characteristics, the so-called HLA molecules.
Only with the most accurate fit is there a good chance that the recipient's body will not reject the donor's cells.
The greatest likelihood of compatibility is with siblings, and nowadays there are also extensive databases in which the HLA characteristics numerous voluntary donors are stored.
A Stem cell transplant can be used therapeutically for some Forms of leukemia, Hodgkin-Lymphoma and Non-Hodgkin-Lymphoma, Immunodeficiency, hematological Diseases like Thalassemia and others.