.jpg)
.jpg)
Antiemetic, dopamine-2 receptor blocker
Metoclopramide belongs to the class of antiemetics and gastrokinetics and is therefore an anti-nausea medication. That is, it relieves the feeling of vomiting and nausea by stimulating the movement of the upper gastrointestinal tract.
Metoclopramide (MCP) is a so-called Dopamine antagonist. An antagonist is a substance attached to you specific receptor binds and blocked it so that the actual messenger substance does not work can.
$config[ads_text1] not found
Dopamine is a body-specific messenger substance the nervous system, which can transmit signals between two neurons and for control mental and physical activities responsible for. Dopamine is involved in the following functions:
In certain activities, e.g. when eating, it acts as a Happiness hormone. Additionally, dopamine has one Vomit triggering property that can be set with the help of Antagonists (Receptor blockers) inhibited can be. There are two types of dopamine receptor blockers:
You can the Blood-brain barrier hardly overcome and so have little effect on that brain. Metoclopramide (MCP) is one of the peripheral, so not in the brain, acting drugs and only crosses the blood-brain barrier in low concentrations. It can still become a sedative, antipsychotic Effect come.
$config[ads_text2] not foundMCP also reacts with other receptors. It inhibits the 5-HT3 receptors and activates the 5-HT4 receptors. Both work on them Movement processes of the gastrointestinal tractso that metoclopramide also does that Excretion of water and electrolytes promotes.
Metoclopramide (MCP) should just as taken be like it the doctor has prescribed. The normal dose is for an adult 36 drops 3-4 times a day. For teenagers 2-3 times 18-36 drops per day and in children it will based on body weight of all things. At impaired liver or kidney function is the Adjust dose from doctor.
Due to rare but severe neurological and cardiovascular side effects the EU Commission decided in April 2014 to include metoclopramide in its
to restrict. So may Infants no metoclopramide (MCP) get more and adults and teenagers should a maximum of five days receive. The Maximum dose for drops lies by 1mg / ml, for parenteral preparation (via the vein) is the limit value at 5 mg / ml and for Suppositories became a limit of the active substance content of 20 milligrams arranged.
Metoclopramide (MCP) is a antiemetic drug and is used for the following symptoms:
$config[ads_text3] not found
According to the new law, it is allowed can no longer be prescribed at gastrointestinal motility disorders or Reflux esophagitis (Inflammation of the esophagus due to acid regurgitation of the stomach contents), as there was insufficient evidence of clinical effectiveness. In addition, it may only be used after delayed, chemotherapy-induced Nausea and vomiting be prescribed.
$config[ads_text2] not foundAs with other drugs, metroclopramide (MCP) has contraindications, which can prevent the Taking metoclopramide is excluded:
children under two years allowed to no metoclopramide (MCP).
In certain circumstances, metoclopramide (MCP) taken with caution become.
Caution should be exercised when using:
If you experience any of the following side effects during treatment with metoclopramide (MCP), the Interrupted use of the drug and a Consulted a doctor become.
$config[ads_text4] not found
Common side effects are:
Rarely there can be side effects of metoclopramide (MCP) too
come.
In adults, symptoms similar to Parkinson's disease may in rare cases Muscle tremors, Muscle stiffness or Sedentary lifestyle come. In children, after taking metoclopramide (MCP), the so-called dyskinetic syndrome occur. It refers to involuntary, convulsive movements of the head and shoulder region.
Other side effects of metoclopramide (MCP) can occur
If other drugs have been taken or recently taken, this must be reported to the attending physician, as the use of metoclopramide (MCP) can lead to interactions with other drugs.
By taking metoclopramide (MCP), other drugs can be strengthened or prolonged in their effect. Which includes:
The effects of cimetidine or digoxin can be reduced by taking metoclopramide (MCP). When taking MCP and neuroleptics or serotonin reuptake inhibitors (SSRIs), e.g. Fluoxetine, "extrapyramidal symptoms" may occur more intensely. These include symptoms of cramps in the head, neck and shoulder area. Coordinated motor movements are no longer possible here.
