Formation of mineral corticoids:
To those in the Zona glomerulosa synthesized hormones include aldosterone and corticosterone. The output for the production of these hormones is provided by cholesterol via pregnenolone and progesterone. Through further enzymatic changes (hydroxylation, oxidation) the mineral corticoids are ultimately formed. The corticosterone formed is converted to aldosterone.
The receptor is intracellular and there is no specific transport protein in the blood.
Regulation of mineral corticoids:
The aldosterone release is determined by the blood pressure as well as the blood volume Angiotensin 2 and through the mirrors of sodium and potassium determined in the blood. Angiotensin II is a tissue hormone (Peptide hormone), which is released as part of the renin-angiotensin-aldosterone system. This system is used to regulate blood pressure and the water and electrolyte balance. A low blood volume and a low blood pressure, a high potassium and a low sodium level increase the aldosterone concentration. In addition, the pituitary ACTH and beta-adrenergic substances stimulate (adrenaline, Norepinephrine) the release of aldosterone. This is inhibited by the peptide hormone atriopeptin of the atrium and dopamine.
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The hormone Aldosterone As a representative of the mineral corticoids, it is responsible for the fluid, sodium, potassium and acid-base balance. It has an increasing effect on blood volume and blood pressure.
