Active ingredient

Combination preparation made from St. John's wort (Hyperici herba Extr. Sicc.) and valerian root (Valerianae radix Extr.sicc.)


Sedariston® is available in the form of capsules or drops.

Sedariston® is an active ingredient combination of St. John's wort and valerian in the form of capsules or drops, which does not require a prescription.

It is a herbal medicine that is primarily intended to calm down and relieve depressive or anxious symptoms.

Although it is a herbal preparation, possible interactions with other drugs should not be underestimated.

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The attending physician should also always be informed about the intake of Sedariston® so that he can assess the risk of such interactions and react accordingly.

Read more on the topic: Sedatives

Side effects

The intake of Sedariston® can - depending on the dose - lead to one Limitation of responsiveness lead so inadequate driving ability more is guaranteed.

When taking Sedariston®, it is not uncommon for the skin to be over-sensitive to light, a so-called Photosensitization.
This can get through sunburn-like redness or Blistering show even with little sun contact.

It can be rarer too allergic reactions With skin rash (Rash) come.

Furthermore symptoms such as Dry mouth, a headache, fatigue and Drowsiness but also Restlessness as well as slight gastrointestinal complaints such as nausea, stomach pain and diarrhea occur.

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In rare cases Sedariston® leads to an excessive effect, so that the person affected in a excessive high spirits (mania) expires.


Sedariston® contains the calming herbal remedy valerian.

If you take other sedative drugs at the same time, such as some drugs from the group of tricyclic antidepressants and sleeping pills, this calming and sedating effect can be significantly increased.

The same applies to alcohol consumption during treatment with Sedariston®.

Even before planned anesthesia, the drug should be discontinued in good time, as this can also lead to an unpredictable increase in sedation.

The second component of Sedariston®, St. John's wort, is responsible for its further interactions.

Since St. John's wort can cause the skin to be overly sensitive to light, this effect can be significantly increased if other drugs with such a side effect are taken at the same time.

Which includes:

  • some antibiotics (for example tetracyclines such as doxycycline),
  • some representatives from the group of non-steroidal anti-inflammatory drugs (NSAIDs) to reduce pain (for example piroxicam and tiaprofenic acid),
  • some drugs from the group of water tablets, i.e. diuretics (for example hydrochlorothiazide),
  • some representatives of psychotropic drugs (for example haloperidol and numerous tricyclic antidepressants such as amitriptyline),
  • Antimalarial agents such as quinine or chloroquine,
  • some medicines for high blood pressure (for example captopril and nifedipine) and hypercholesterolemia (for example clofibrate),
  • some anti-diabetic drugs such as glibenclamide,
  • some oral contraceptives ("Pill")
  • Retinoids, which are used, for example, to treat acne

Amiodarone, used to treat cardiac arrhythmias, can also increase photosensitivity.

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Simultaneous use of Sedariston® and antidepressants from the group of serotonin reuptake inhibitors (for example paroxetine) is prohibited as it can lead to the development of a life-threatening serotonin syndrome. Symptoms such as fever, sweating, confusion and a drop in blood pressure up to a coma appear.

With other antidepressants too, simultaneous use with Sedariston® should be avoided.

St. John's wort activates certain degrading enzymes in the liver (Enzyme inducer), which means that many drugs are broken down more quickly and are therefore less effective.

These drugs include such vital drugs as the immunomodulators tacrolimus and ciclospoprin A for the treatment of organ transplant patients in order to avoid rejection of the organ.

Medicines for the treatment of patients suffering from AIDS, such as indinavir, can also become less effective if St. John's wort is taken at the same time.


  • Heart failure drugs such as digitoxin,
  • Sedatives from the group of benzodiazepines such as midazolam,
  • Drugs from the group of tricyclic antidepressants such as amitriptyline,
  • Blood thinning medication (Anticoagulation) like phenprocumon and warfarin,
  • Drugs used to treat cancer, such as imatinib and irinotecan,
  • oral contraceptives ("Pill").


Sedariston® should be taken at the same time and with a little fluid every day if possible.

In patients with a sensitive stomach it should be stopped not on an empty stomach but rather during or after a meal.

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Unless otherwise agreed with the doctor, adults should 4 capsules daily Take Sedariston®.

Either 1 capsule each morning, noon, afternoon and evening or 2 capsules each morning and evening.

If you have trouble sleeping, the last capsule (s) should be taken about half an hour before going to bed.

Sedariston® is usually used for several weeks. If there is no improvement, a doctor should be consulted again.

Application / indications

Sedariston® can be used as a herbal remedy in the treatment of Restlessness and nervousness, unrest-related sleep disorders as well as easy with moderate depressive moods and Anxiety disorders.

The active ingredient unfolds valerian especially the calming and sleep-inducing effect during the Johannis herbs Can help reduce symptoms of depression and anxiety.


Sedariston® should not be taken in case of known hypersensitivity to Johannis herbs or valerian.

Furthermore, while taking Sedariston®, excessive light exposure, for example in the form of visits to the solarium and long stays in the sun, should be avoided or Sedariston® should not be consumed.
Alternatively, excessive exposure to light should be avoided by taking adequate sun protection measures.

Sedariston® may not for severe depression and also not in combination with other antidepressants be taken.

In patients who like immunomodulators Ciclosporin and Tacrolimus, Blood thinners like Phenprocumon or Warfarin as well as taking drugs for AIDS therapy, Sedariston® must not be used.

With contraception using the pill (oral contraception) additional contraceptive measures should be used to ensure adequate contraception.

Neither for children under 12 years nor for women in pregnancy and Lactation Sufficient results are available for therapy with Sedariston®, so that therapy should be avoided here.


The costs for Sedariston® can vary depending on the provider, the information listed does not necessarily include the lowest possible price.

30 capsules Sedariston® with 275 mg valerian root and 600 mg of St. John's wort cost about 7.50 euros. 60 capsules cost about 13.86 euros.100 capsules cost about 16.95 euros.

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100 ml Sedariston® drops cost about 16.25 euros.

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