Prostaglandins are formed by the body and have a variety of effects, ranging from reducing gastric juice production to affecting the tone of the smooth muscles and the cardiovascular system. In addition to these effects, an increased drainage of aqueous humor, which is associated with a decrease in intraocular pressure, can also be observed.
Read more on the subject at: Prostaglandins
The reduction of intraocular pressure is done in the glaucoma therapy (glaucoma) advantage. The following substances are used: Bimatoprost (Lumigan), Latanoprost (Xalatan), Travoprost (Travatan) and Unoprostone (Rescula). The Eyeruff should be taken once a day. More frequent use carries the risk that the intraocular pressure lowering effect can be reduced. Prostaglandin derivatives can also be used in combination with Beta blockers can be applied. The drug can still be detected 4-6 weeks after discontinuation (washout time).
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The effect of prostaglandin derivatives on Kidney and liver damage have not yet been investigated. Medicines belonging to this group should be used with caution in patients with corresponding comorbidities. Patients receiving prostaglandin derivatives should be informed that the eyelashes may grow faster and the pigmentation of the eyes may change, resulting in a different appearance in both eyes. Furthermore, allergies, uveitides and conjunctival hyperemia (Red eyes) observed during treatment.
In patients with hypersensitivity to Prostaglandins as well as an existing inflammation of the uvea, the Conjunctiva as well as viral Infections of the eye prostaglandin derivatives should not be given or given only with particular caution. Furthermore, medication should be administered with caution in patients with known impaired liver or kidney function.
